Studies on the biosynthesis of clavulanic acid. I. Incorporation of 13C-labelled precursors.

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The Use of 13C in the Synthesis of Double Labelled Precursors

Discovery of 13C NMR and its application in the biosynthetic pathways prompted the synthesis of several 13C labelled precursors. To investigate the metabolism of phenyllactic acid in the Solanaceae family, the double labelled acid was synthesized from barium carbonate (13C) and sodium syanide (13C)

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the use of 13c in the synthesis of double labelled precursors

discovery of 13c nmr and its application in the biosynthetic pathways prompted the synthesis of several 13c labelled precursors. to investigate the metabolism of phenyllactic acid in the solanaceae family, the double labelled acid was synthesized from barium carbonate (13c) and sodium syanide (13c)

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A butenolide intermediate in methylenomycin furan biosynthesis is implied by incorporation of stereospecifically 13C-labelled glycerols.

The label from [3-(13)C]-L-glycerol is incorporated into the hydroxymethyl group of methylenomycin furans suggesting a butenolide intermediate in their biosynthesis.

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ژورنال

عنوان ژورنال: The Journal of Antibiotics

سال: 1978

ISSN: 0021-8820,1881-1469

DOI: 10.7164/antibiotics.31.586